L-glutamic acid dibenzyl diester hydrochloride, CAS No. 4561-10-8

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4561-10-8

Catalog No. EBD433076

CAS 4561-10-8

Name L-glutamic acid dibenzyl diester hydrochloride

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Basic Information

Synonyms: dibenzylL-glutamatehydrochloride(1:1) H-Glu(Obzl)-ObzlHcl H-Glu(OBzl)-OBzl·HCl L-glutamicaciddibenzyldiesterhydrochloride L-glutamicaciddibenzylesterhydrochloride N-glutamicaciddibenzylesterhydrochloride L-glutamicacidbenzylesterhydrochloride glutamicaciddibenzylesterhydrochloride dibenzylL-glutamatehydrochloride H-L-Glu-(OBn)-OBnhydrochloride

Molecular Formula: C19H22NO4*Cl

Molecular Weight: 363.84

MDL Number: MFCD00035103

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

L-Glutamic acid dibenzyl ester hydrochloride is a protected derivative of the amino acid L-glutamic acid. It features benzyl ester groups protecting the carboxylic acid functionalities, making it a crucial intermediate in peptide synthesis. The hydrochloride salt form enhances its stability and handling properties. This compound is primarily employed as a key building block in the solid-phase and solution-phase synthesis of peptides and peptidomimetics. Its main application lies in the pharmaceutical industry for the research and development of peptide-based drugs, where it serves to introduce the glutamic acid residue while preventing unwanted side reactions during the coupling steps. It is a standard reagent for constructing specific peptide sequences. As a protected amino acid derivative, it is a staple in medicinal chemistry and biochemistry laboratories for constructing complex biomolecules. Proper handling requires standard laboratory safety precautions due to its potential irritant properties.

Physical Properties

Boiling Point: 453.5 °C at 760 mmHg

Flash Point: 165.6 °C