2-Chloro-5-nitrobenzene-1-sulfonyl chloride, CAS No. 4533-95-3

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4533-95-3

Catalog No. EBD10556

CAS 4533-95-3

Name 2-Chloro-5-nitrobenzene-1-sulfonyl chloride

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Basic Information

Synonyms: 2-Chloro-5-nitrobenzene-1-sulfonylchloride 2-Chloro-5-nitrobenzenesulfonylchloride Benzenesulfonylchloride,2-chloro-5-nitro- NSC350627 2-Chloro-5-nitrobenzenesulphonylchloride 2-Chloro-5-nitro-benzenesulfonylchloride

Molecular Formula: C6H3Cl2NO4S

Molecular Weight: 256.06

MDL Number: MFCD00129813

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Basic Synthetic Reagents > Halogenation Reagents

Product Description:

2-Chloro-5-nitrobenzenesulfonyl chloride is an organic compound featuring both a sulfonyl chloride group and a nitro group on a chlorinated benzene ring. It is a versatile and highly reactive bifunctional reagent, primarily serving as a key intermediate in organic synthesis. Its primary application lies in its use as a sulfonylation reagent. The sulfonyl chloride group readily reacts with nucleophiles such as amines and alcohols to form sulfonamides and sulfonate esters, respectively. This makes it a valuable building block for the synthesis of various sulfonamide derivatives, which are important structural motifs in pharmaceuticals, agrochemicals, and materials science. The presence of the nitro and chloro groups provides additional handles for further functionalization via substitution or reduction reactions. Due to its high reactivity, it must be handled with care under anhydrous conditions. It is typically used as a reagent for introducing the 2-chloro-5-nitrophenylsulfonyl moiety into target molecules, facilitating the construction of complex chemical architectures.

Physical Properties

Melting Point: 88-90°C

Boiling Point: 371.6 °C at 760 mmHg

Flash Point: 178.5 °C

Density: 1.708 g/cm3

Analytical Data

Appearance: Solid