2-Fluoro-5-methylaniline, CAS No. 452-84-6

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452-84-6

Catalog No. EBD20472

CAS 452-84-6

Name 2-Fluoro-5-methylaniline

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Basic Information

Synonyms: 3-Amino-4-fluorotoluene~6-Fluoro-m-toluidine 2-Fluoro-5-methylbenzeneamine 6-Fluoro-m-toluidine 3-Amino-4-fluorotoluene 2-Fluoro-5-methylaniline

Molecular Formula: C7H8FN

Molecular Weight: 125.14

MDL Number: MFCD00007654

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Fluoro-5-methylaniline is an organic compound featuring an amino group attached to a benzene ring substituted with fluorine and methyl groups at the 2- and 5- positions, respectively. It is a light yellow to brown liquid or crystalline solid with a molecular formula of C7H8FN. This compound serves as a crucial building block in pharmaceutical synthesis. It is notably used as a key intermediate in the production of various active pharmaceutical ingredients (APIs). For instance, it is a core fragment in the synthesis of tyrosine kinase inhibitors, such as certain anticancer drugs, and other biologically active molecules where the fluoro-methyl-aniline moiety is essential for target binding and modulating pharmacokinetic properties. As a substituted aniline, it is a versatile reagent in organic chemistry, participating in reactions typical of aromatic amines, such as diazotization and amide bond formation. Proper handling is required due to its potential toxicity and irritant properties.

Physical Properties

Boiling Point: 80-86 °C/11 mmHg(lit.)

Flash Point: 82 °C

Density: 1.109 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.533(lit.)

Analytical Data

Appearance: clear yellow to brown liquid