Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    448-19-1

    Catalog No. EBD24855

    CAS 448-19-1

    Name 5-Fluoro-2-nitroanisole

    Get Quote
    Basic Information

    Synonyms: 4-Fluoro-2-methoxy-1-nitrobenzene 5-Fluoro-2-nitroanisole

    Molecular Formula: C7H6FNO3

    Molecular Weight: 171.13

    MDL Number: MFCD00077541

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    5-Fluoro-2-nitroanisole is an organic compound with the molecular formula C7H6FNO3. It is a pale yellow to yellow crystalline solid. Structurally, it is a substituted anisole featuring both a fluorine atom and a nitro group on the benzene ring, making it a versatile aromatic building block. This compound is primarily used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its specific substitution pattern allows for further functionalization, such as reduction of the nitro group to an amine, which is a common step in constructing more complex molecules. It serves as a crucial precursor in the production of certain fluoroquinolone antibiotics and other active pharmaceutical ingredients (APIs) that contain a fluorinated aromatic moiety. As a bifunctional synthon containing both a halogen (fluorine) and a nitro group, it is also employed in organic synthesis research for cross-coupling reactions and nucleophilic aromatic substitution reactions. Standard safety precautions for handling nitroaromatic compounds should be observed.
    Physical Properties

    Melting Point: 49-51°C

    Boiling Point: 245.8 °C at 760 mmHg

    Flash Point: 102.5 °C

    Density: 1.321 g/cm3

    mg g kg ml l t