5-Fluoro-2-nitrophenol, CAS No. 446-36-6

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446-36-6

Catalog No. EBD46073

CAS 446-36-6

Name 5-Fluoro-2-nitrophenol

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Basic Information

Synonyms: 3-FLUORO-6-NITROPHENOL 2-Nitro-5-Fluorophenol 5-Fluoro-2-nitrophenol,98% 5-Fluoro-2-nitrophenol99% 5-FLUORO-2-NITROPHENOL,2-NITRO-5-FLUOROPHENOL PHENOL,5-FLUORO-2-NITRO 5-Fluoro-2-nitro-phenol 5-fluoro-2-nitrophenolate 5-Fluoro-2-nitrophenol

Molecular Formula: C6H4FNO3

Molecular Weight: 157.1

MDL Number: MFCD00007107

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

5-Fluoro-2-nitrophenol is a fluorinated nitrophenol derivative. Its structure features a benzene ring substituted with a hydroxyl group (-OH), a nitro group (-NO2), and a fluorine atom (-F) at the 5-position. This compound serves as a key building block in organic synthesis, particularly for constructing more complex molecules. Its primary application is as a pharmaceutical intermediate, specifically a small molecule drug fragment. The presence of both electron-withdrawing (nitro, fluoro) and electron-donating (hydroxy) groups makes it a versatile precursor for synthesizing bioactive compounds, including potential drug candidates for various therapeutic areas. The fluorine atom is often introduced to modulate metabolic stability and lipophilicity in drug design. As a synthetic building block, it is classified under halogenated compounds. It can undergo further transformations, such as reduction of the nitro group to an amine, or functionalization of the hydroxyl group, enabling the construction of heterocycles and other complex scaffolds. It is a standard reagent in medicinal chemistry and materials science research.

Physical Properties

Melting Point: 34-37 °C(lit.)

Boiling Point: 260°C

Flash Point: 91 °C

Density: 1.511 g/cm3

Solubility: slightly soluble

Analytical Data

Appearance: white to light yellow crystal powder