4-Fluoro-2-methyl-1-nitrobenzene, CAS No. 446-33-3

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446-33-3

Catalog No. EBD25985

CAS 446-33-3

Name 4-Fluoro-2-methyl-1-nitrobenzene

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Basic Information

Synonyms: 5-Fluoro-2-nitrotoluene Fluoronitrotoluene5 2-Nitro-5-FluoroToluene 4-Fluoro-2-methyl-1-nitrobenzene 3-Fluoro-6-Nitrotoluene

Molecular Formula: C7H6FNO2

Molecular Weight: 155.13

MDL Number: MFCD00007283

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

5-Fluoro-2-nitrotoluene is an organic compound with the molecular formula C7H6FNO2. It is a pale yellow to yellow crystalline solid. Structurally, it is a toluene derivative substituted with a fluorine atom at the 5-position and a nitro group at the 2-position. This compound is primarily used as a key pharmaceutical intermediate. It serves as a crucial building block in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing a fluorinated aromatic core. A notable application is its role in the synthesis of fluoroquinolone antibiotics, such as ciprofloxacin and norfloxacin, where it contributes the fluorinated aromatic moiety essential for their antibacterial activity. As a versatile synthetic building block, it is also employed in organic research for the preparation of other fluorinated aromatic compounds, dyes, and agrochemicals. Its reactivity stems from the presence of both an electron-withdrawing nitro group and a halogen atom, making it amenable to nucleophilic aromatic substitution and reduction reactions.

Physical Properties

Melting Point: 28°C

Boiling Point: 97-98 °C/10 mmHg(lit.)

Flash Point: 88 °C

Density: 1.272 g/mL at 25 °C(lit.)

Solubility: Insoluble in water

Refractivity: n20/D 1.527(lit.)

Analytical Data

Appearance: Colorless to light yellow liquid