2-amino-5-fluoro-benzoic acid, CAS No. 446-08-2

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

446-08-2

Catalog No. EBD9229

CAS 446-08-2

Name 2-amino-5-fluoro-benzoic acid

Get Quote

Basic Information

Synonyms: 4-fluoroanthranilicacid 2-amino-5-fluoro-benzoicacid 2-Amino-5-fluorobenzoicacid RARECHEMALBO2236 5-FLUOROANTHRANILICACID BUTTPARK19\04-54 AURORAKA-5382 5-FluoroanthranilicAcid/2-Amino-5-FluorobenzoicAcid 2-Amino-5-fluoroBenzoicacid97. 2-Amino-5-fluorobenzoicAcid,5-FAA 2-Amino-5-fluorobenzoic 2-Amino-5-fluorobenzoicacid97.5% 2-AMINO-5-FLUOROBENZOICACID99+% 5-FLUOROANTHRANILICACID98+% 2-Amino-5-fluorobenzoicacid(5-Fluoroanthranilicacid) 2-amino-5-fluorobenzoate 2-Amino-5-fluoroBenzoica

Molecular Formula: C7H6FNO2

Molecular Weight: 155.13

MDL Number: MFCD00055566

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2-Amino-5-fluorobenzoic acid is a fluorinated aromatic amino acid derivative featuring both an amino group and a carboxylic acid group on a benzene ring, with a fluorine atom at the 5-position. This compound serves as a key building block in pharmaceutical synthesis, particularly for constructing heterocyclic systems such as quinazolines, benzodiazepines, and other fused ring structures. Its fluorine substituent enhances metabolic stability and bioavailability in drug candidates. In medicinal chemistry, it is widely employed as an intermediate for developing anticancer agents, anti-inflammatory drugs, and central nervous system (CNS) therapeutics. For example, it is a precursor in the synthesis of certain tyrosine kinase inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs). The compoundбпs dual functionality allows for versatile derivatization, including amidation, esterification, and cyclization reactions. As a general synthetic building block, it is also utilized in organic chemistry for preparing fluorinated analogs of bioactive molecules and agrochemicals. Its moderate reactivity and stability make it suitable for standard coupling and condensation reactions. Safety precautions should be taken due to potential irritation upon contact.

Physical Properties

Melting Point: 181-183 °C(lit.)

Boiling Point: 318.2 °C at 760 mmHg

Flash Point: 146.2 °C

Density: 1.43 g/cm3

Analytical Data

Appearance: white to light yellow crystal powder