(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, CAS No. 4419-39-0

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4419-39-0

Catalog No. EBD78445

CAS 4419-39-0

Name (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

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Basic Information

Synonyms: (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one beclomethasone 4419-39-0 beclometasone17,21-dipropionate 9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyldipropanoate (8S,10S,11S,13S,16S)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Molecular Formula: C22H29ClO5

Molecular Weight: 408.92

Categories: Medicinal Chemistry > APIs and Their Salts > Respiratory Drugs Medicinal Chemistry > APIs and Their Salts > Dermatological Drugs

Product Description:

Beclomethasone is a synthetic glucocorticoid steroid. Its chemical name is (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one. It is a white to creamy-white crystalline powder that is practically insoluble in water. The primary application of beclomethasone is as an active pharmaceutical ingredient (API) in inhaled corticosteroid medications for the prophylactic management of asthma. It works by reducing inflammation and swelling in the airways. It is also used topically as a potent corticosteroid for treating various inflammatory skin conditions such as eczema and psoriasis, typically in the form of creams or ointments. Beclomethasone is commonly administered via metered-dose inhalers (e.g., beclomethasone dipropionate). As a potent steroid, its use requires medical supervision to manage potential side effects, especially with long-term systemic exposure. It is a key drug listed in the World Health Organization's Model List of Essential Medicines.

Physical Properties

Melting Point: 217- 222°C (dec.)

Boiling Point: 600.2°C at 760 mmHg

Flash Point: 316.8°C

Density: 1.35g/cm3

Storage: 2-8°C

Analytical Data

Appearance: White to off-white solid