Trifluoperazine dihydrochloride, CAS No. 440-17-5

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440-17-5

Catalog No. EBD52029

CAS 440-17-5

Name Trifluoperazine dihydrochloride

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Basic Information

Synonyms: Trifluoperazinehydrochloride 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluormethyl)-10H-phenothiazinhydrochlorid 10-[3-(4-méthylpipérazin-1-yl)propyl]-2-(trifluorométhyl)-10H-phénothiazinechlorhydrate 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazinehydrochloride 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazinehydrochloride(1:1) 10H-phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-,hydrochloride(1:1) 10H-phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-,monohydrochloride TrifluoperazineHCl Trifluoperazinehydrochloride(VAN) Trifluoperazinehydrochloride[JAN] hydrogenchloride10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine(1:1:1) Trifluoperazinedihydrochloride 10-[3-(4-méthylpipérazin-1-yl)propyl]-2-(trifluorométhyl)-10H-p

Molecular Formula: C21H26Cl2F3N3S

Molecular Weight: 480.42

MDL Number: MFCD00012656

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Trifluoperazine dihydrochloride is the dihydrochloride salt form of trifluoperazine, a typical phenothiazine derivative. It is a white to off-white crystalline powder. The compound is a potent antipsychotic agent belonging to the piperazine subclass of phenothiazines. Its primary application is as an active pharmaceutical ingredient (API) for the treatment of schizophrenia and other psychotic disorders. It functions as a dopamine receptor antagonist, particularly at D2 receptors, and also exhibits significant antiemetic properties. It is used in the management of anxiety and non-psychotic behavioral disorders. Furthermore, trifluoperazine dihydrochloride is commonly used as a reference standard or impurity standard in pharmaceutical quality control and analytical research to ensure the purity and identity of the drug substance. The compound requires careful handling due to its pharmacological activity. It is associated with extrapyramidal side effects common to typical antipsychotics. It is typically administered orally in tablet form.

Physical Properties

Color: white to off-white

Melting Point: 243 °C (dec.)(lit.)

Boiling Point: 506 °C at 760 mmHg

Flash Point: 259.8 °C

Storage: −20°C

Analytical Data

Appearance: Cream fine powder