2-Amino-6-fluorobenzoic acid, CAS No. 434-76-4

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434-76-4

Catalog No. EBD18543

CAS 434-76-4

Name 2-Amino-6-fluorobenzoic acid

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Basic Information

Synonyms: 2-amino-6-fluorobenzoate 6-Fluoroanthranilicacid 2-Amino-6-fluorobenzoicacid anthralicacid,6-fluoro-

Molecular Formula: C7H6FNO2

Molecular Weight: 155.13

MDL Number: MFCD00067781

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Amino-6-fluorobenzoic acid is an organic compound featuring both an amino group and a carboxylic acid group on a fluorinated benzene ring. This bifunctional structure makes it a versatile building block in synthetic chemistry. Its primary and most significant application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly fluoroquinolone antibiotics. The presence of both the fluorine atom and the ortho-aminobenzoic acid moiety is essential for constructing the core quinolone scaffold, which is vital for the antibacterial activity of these drugs. Beyond its role in antibiotic synthesis, this compound is also utilized in the preparation of other heterocyclic compounds and as a starting material for agrochemicals and dyes. Its dual functionality allows for diverse chemical transformations, including cyclization and amide bond formation.

Physical Properties

Melting Point: 167-169 °C(lit.)

Boiling Point: 308.8 °C at 760 mmHg

Flash Point: 140.5 °C

Density: 1.43 g/cm3

Analytical Data

Appearance: white to light yellow crystal powder