Trifluoroacetophenone, CAS No. 434-45-7

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434-45-7

Catalog No. EBD39

CAS 434-45-7

Name Trifluoroacetophenone

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Basic Information

Synonyms: 2,2,2-Trifluoroacetophenone Trifluoroacetophenone Alpha,Alpha,Alpha-Trifluoroacetophenone Phenyltrifluoromethylketone 2,2,2-Trifluoro-1-phenylethanone

Molecular Formula: C8H5F3O

Molecular Weight: 174.12

MDL Number: MFCD00000420

Categories: Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

Product Description:

Α,α,α-Trifluoroacetophenone is an organic compound with the molecular formula C8H5F3O. It is a colorless to pale yellow liquid characterized by a ketone functional group where the methyl hydrogens are fully substituted by fluorine atoms, making it a highly electron-deficient and reactive aromatic ketone. This compound is primarily utilized as a versatile building block and reagent in organic synthesis. Its strong electron-withdrawing trifluoromethyl group adjacent to the carbonyl significantly activates the molecule towards nucleophilic addition reactions and facilitates the formation of various heterocyclic systems. It serves as a key precursor in the synthesis of pharmaceuticals, agrochemicals, and liquid crystal materials. Specifically, it is employed in the preparation of trifluoromethyl-substituted pyrazoles, isoxazoles, and other important bioactive heterocycles. As a reactive synthon, it is also used in studies involving fluorinated compounds and as a model substrate in catalytic reactions. Handling requires standard precautions for flammable organic liquids, and it should be stored in a cool, well-ventilated area away from ignition sources and strong bases.

Physical Properties

Melting Point: -40 °C

Boiling Point: 165-166 °C(lit.)

Flash Point: 41 °C

Density: 1.24 g/mL at 25 °C(lit.)

Solubility: PRACTICALLY INSOLUBLE

Refractivity: n20/D 1.458(lit.)

Storage: Flammables area

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 1224C

Analytical Data

Appearance: clear colorless to yellow liquid