6-chloro-3-methyl-1H-pyrimidine-2,4(1H,3H)-dione, CAS No. 4318-56-3

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4318-56-3

Catalog No. EBD49631

CAS 4318-56-3

Name 6-chloro-3-methyl-1H-pyrimidine-2,4(1H,3H)-dione

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Basic Information

Synonyms: 6-Chloro-3-methyluracil 3-Methyl-6-chlorouracil 6-chloro-3-methyl-2,4(1H,3H)-pyrimidinedione 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione 6-Chloro-3-dimethyluracil 3-METHYL-6-CHLOROURACI 6-Chloro-3-Methyuracil 3-Methyl-6-chlorouracil,GC97% 6-chloro-3-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Molecular Formula: C5H5ClN2O2

Molecular Weight: 160.56

MDL Number: MFCD01074837

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

6-Chloro-3-methyluracil is a heterocyclic organic compound featuring a pyrimidine ring substituted with a chlorine atom at the 6-position and a methyl group at the 3-position. It serves as a versatile and important synthetic building block in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of various pharmaceutical compounds. Notably, it is a crucial precursor in the production of theophylline and its derivatives. Theophylline is a well-known methylxanthine drug used in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). The chlorine atom in 6-chloro-3-methyluracil provides a reactive site for further functionalization, enabling the construction of more complex molecular architectures. As a halogenated uracil derivative, it is a fundamental heterocyclic scaffold. Its reactivity makes it valuable for researchers in organic synthesis, particularly for constructing fused heterocyclic systems or introducing specific substitutions on the pyrimidine core.

Physical Properties

Melting Point: 278-280°C (dec.)

Boiling Point: 268.7 °C at 760 mmHg

Flash Point: 116.3 °C

Density: 1.51 g/cm3