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    426253-04-5

    Catalog No. EBD2761215

    CAS 426253-04-5

    Name (4R,5S,6S)-3-[[4-[(5S)-2,5-Dihydro-5-methyl-1H-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

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    Basic Information

    Molecular Formula: C18H21N3O4S2

    Molecular Weight: 407.51

    Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > APIs and Their Salts > Other Drugs

    Product Description:
    (4R,5S,6S)-3-[[4-[(5S)-2,5-Dihydro-5-methyl-1H-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, with CAS number 426253-04-5, is a complex carbapenem derivative. Its structure features a fused beta-lactam ring system characteristic of carbapenem antibiotics, substituted with a thiazole-thioether side chain and a dihydropyrrole moiety. This compound is a key synthetic intermediate in the production of advanced carbapenem antibiotics. Specifically, it is a crucial precursor in the synthesis of Doripenem, a broad-spectrum carbapenem antibiotic used to treat serious bacterial infections, including complicated intra-abdominal infections and complicated urinary tract infections. The synthesis involves the final stages of constructing the carbapenem core and introducing the specific side chain responsible for its antibacterial activity and beta-lactamase stability. As a high-value pharmaceutical intermediate, its production and handling require strict control under Current Good Manufacturing Practice (cGMP) conditions to ensure purity and consistency for the final API manufacturing process. Its primary significance lies in the pharmaceutical industry for the development and production of potent anti-infective agents.
    Physical Properties

    Density: 1.52

    mg g kg ml l t