Isoorientin, also known as homoorientin or luteolin-6-C-glucoside, is a naturally occurring flavonoid C-glycoside. Its chemical structure consists of a luteolin aglycone (a flavone) with a glucose molecule attached at the 6-position via a carbon-carbon bond, making it more stable than O-glycosides against hydrolysis. It is commonly isolated from various plant sources such as passionflower (*Passiflora incarnata*), rooibos tea (*Aspalathus linearis*), and bamboo leaves. This compound exhibits a broad spectrum of pharmacological activities, which underpins its primary research and potential therapeutic applications. It has demonstrated significant antioxidant, anti-inflammatory, and neuroprotective effects in preclinical studies. Research also indicates potential benefits in cardiovascular health, hepatoprotection, and anti-diabetic activities. Its mechanism of action is often linked to the modulation of key signaling pathways (e.g., NF-κB, MAPK) and enzymes, as well as direct free radical scavenging. Due to these bioactive properties, Isoorientin is of considerable interest in the fields of nutraceuticals and natural product-based drug discovery. It serves as a reference standard for quality control of herbal medicines and functional foods. While not yet a mainstream pharmaceutical API, it is actively studied as a lead compound or a key active constituent in botanical extracts for various health applications.