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    42564-51-2

    Catalog No. EBD26545

    CAS 42564-51-2

    Name 4-Fluoro-3-nitrobenzaldehyde

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    Basic Information

    Synonyms: 4-Fluoro-3-nitrobenzaldehyde Benzaldehyde,4-fluoro-3-nitro- 3-Nitro-4-fluorobenzaldehyde

    Molecular Formula: C7H4FNO3

    Molecular Weight: 169.11

    MDL Number: MFCD01861388

    Categories: Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    4-Fluoro-3-nitrobenzaldehyde is an aromatic organic compound featuring both a formyl group and nitro and fluoro substituents on the benzene ring. This specific substitution pattern makes it a versatile and valuable building block in synthetic organic chemistry. Its primary application is as a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules. The aldehyde group serves as a reactive handle for condensation reactions (e.g., to form imines or undergo nucleophilic addition), while the nitro group can be reduced to an amine, enabling the construction of complex heterocyclic systems or aniline derivatives. It is notably used in the synthesis of tyrosine kinase inhibitors and other drug candidates targeting specific biological pathways. As a bifunctional synthon, it is widely employed in academic and industrial research for constructing libraries of compounds for screening. Standard safety precautions for handling nitroaromatic compounds and aldehydes should be observed, including the use of personal protective equipment due to potential irritant properties.
    Physical Properties

    Melting Point: 45-47 °C(lit.)

    Boiling Point: 285.996 °C at 760 mmHg

    Flash Point: >230 °F

    Density: 1.444 g/cm3

    mg g kg ml l t