S-(-)-1-(4-chlorophenyl)-ethylamine, CAS No. 4187-56-8

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4187-56-8

Catalog No. EBD2308355

CAS 4187-56-8

Name S-(-)-1-(4-chlorophenyl)-ethylamine

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Basic Information

Synonyms: S-(-)-1-(4-chlorophenyl)-ethylamine (S)-1-(4-Chlorophenyl)ethylamine (S)-(-)-1-(4-Chlorophenyl)ethylamine (S)-4-Chloro-alpha-methylbenzylamine (1S)-1-(4-chlorophenyl)ethanamine (-)-a-(p-chlorophenyl)ethylamine (-)-p-chloro-a-methylbenzylamine (s)-1-(p-chlorophenyl)ethylamine (s)-4-chloro-a-methylbenzylamine (s)-4-chloro-a-methylbenzenemethanamine benzylamine,p-chloro-a-methyl-,(-)-(8ci) benzenemethanamine,4-chloro-a-methyl-,(s)- (S)-1-(4-Chlorophenyl)ethylamine,producedbyBASFAG

Molecular Formula: C8H10ClN

Molecular Weight: 155.62

MDL Number: MFCD00671640

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-(-)-1-(4-Chlorophenyl)ethanamine is a chiral amine building block characterized by a 4-chlorophenyl group attached to an ethylamine backbone with an (S)-configuration at the chiral center. It is a colorless to pale yellow liquid or low-melting solid with a molecular formula of C8H10ClN. This compound serves as a crucial chiral intermediate in pharmaceutical synthesis. Its primary application is in the preparation of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in the synthesis of selective serotonin reuptake inhibitors (SSRIs) and other central nervous system (CNS) active drugs. The chiral amine moiety is a key pharmacophore for imparting specific biological activity. As a versatile chiral synthon, it is widely used in asymmetric synthesis and medicinal chemistry research. It is commercially available from major chemical suppliers for research and development purposes. Standard safety precautions for handling amines should be observed.

Physical Properties

Boiling Point: 232 °C

Flash Point: 115 °C

Density: 1.110 g/mL at 20 °C(lit.)

Solubility: VERY LOW SOLUBILITY

Refractivity: n20/D 1.543(lit.)

Safety Information

Packing Level: 3

Hazard Category: 6.1/PG

Transport Codes: 2811

Analytical Data

Appearance: Clear colorless to yellowish liquid