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    41825-73-4

    Catalog No. EBD31847

    CAS 41825-73-4

    Name 2-Bromo-4,6-dimethylaniline

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    Basic Information

    Synonyms: Benzenamine,2-bromo-4,6-dimethyl- 2-Bromo-4,6-dimethylbenzenamine 2-Bromo-4,6-dimethylaniline

    Molecular Formula: C8H10BrN

    Molecular Weight: 200.08

    MDL Number: MFCD00047826

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    2-Bromo-4,6-dimethylaniline is an organic compound featuring an aniline core substituted with a bromine atom at the 2-position and methyl groups at the 4- and 6-positions. It is a halogenated aromatic amine with the molecular formula C8H10BrN. This compound typically appears as a solid and serves as a versatile building block in synthetic chemistry. Its primary and significant application is as a key pharmaceutical intermediate. It is notably used in the synthesis of complex drug molecules, including certain non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive compounds. The presence of both the bromine (a good leaving group for cross-coupling reactions) and the amine functionality makes it a valuable precursor for constructing more elaborate molecular architectures through reactions like Buchwald-Hartwig amination or Suzuki coupling. As a substituted aniline derivative, it is a fundamental aromatic amine synthon in organic synthesis laboratories. It must be handled with care due to the potential toxicity associated with aromatic amines and halogenated compounds, requiring appropriate personal protective equipment and ventilation.
    Physical Properties

    Melting Point: 43-47 °C(lit.)

    Boiling Point: 75-79°C 5mm

    Flash Point: 110 °C

    Density: 1.425 g/cm3

    mg g kg ml l t