α-methylpyrrolidine hydrochloride, CAS No. 41720-98-3

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41720-98-3

Catalog No. EBD2638120

CAS 41720-98-3

Name α-methylpyrrolidine hydrochloride

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Basic Information

Synonyms: 2-(R)-methyl-pyrrolidinehydrochloride α-methylpyrrolidinehydrochloride (R)-2-methylpyrrolidine Methylpyrrolidine(S-2-) D-2-Methylpyrrolidine (2R)-2-Methylpyrrolidine 2-(R)-methylpyrrolidine

Molecular Formula: C5H11N

Molecular Weight: 85.15

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-2-Methylpyrrolidine is a chiral, non-natural heterocyclic amine. It features a pyrrolidine ring substituted with a methyl group at the 2-position, and the stereocenter is in the (R)-configuration. This compound is a colorless to pale yellow liquid under ambient conditions. Its primary and most significant application is as a versatile chiral building block and intermediate in pharmaceutical synthesis. The pyrrolidine scaffold is a privileged structure found in numerous bioactive molecules. The (R)-2-methylpyrrolidine moiety is specifically incorporated into the structures of various active pharmaceutical ingredients (APIs), serving as a key chiral synthon. It is notably used in the synthesis of certain antiviral and central nervous system (CNS) active drugs, where the specific stereochemistry is crucial for biological activity and binding affinity. Beyond its direct pharmaceutical use, it also serves as a chiral ligand precursor or auxiliary in asymmetric synthesis and as a base in organic transformations. Due to its basic nature and potential volatility, appropriate safety measures, including handling in a well-ventilated area and using personal protective equipment, are recommended.

Physical Properties

Boiling Point: 100.2 °C at 760 mmHg

Flash Point: 7 °C

Density: 0.842 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.4353

Storage: 2-8°C

Safety Information

Packing Level: II

Hazard Category: 8(3)

Transport Codes: 2924

Analytical Data

Appearance: white crystal powder