boc-p-fluoro-L-phenylalanine, CAS No. 41153-30-4

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41153-30-4

Catalog No. EBD106316

CAS 41153-30-4

Name boc-p-fluoro-L-phenylalanine

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Basic Information

Synonyms: Boc-4-Fluoro-L-Phe-OH Boc-4-Fluoro-L-phenylalanine (S)-N-BOC-4-Fluorophenylalanine Boc-L-4-Fluorophenylalanine boc-p-fluoro-L-phenylalanine (S)-2-((tert-butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoicacid tert-butoxycarbonyl-4-fluorophenylalanine N-Boc-L-p-fluorophenylalanine Boc-L-Phe(4-F)-OH Boc-L-p-F-Phe-OH N-tert-Butoxycarbonyl-4-fluorophenyl-L-alanine

Molecular Formula: C14H18FNO4

Molecular Weight: 283.3

MDL Number: MFCD00079672

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Boc-L-4-Fluorophenylalanine is a protected amino acid derivative featuring a Boc (tert-butoxycarbonyl) group on the amine and a 4-fluorophenyl group on the side chain. It serves as a crucial chiral building block in the synthesis of peptides and peptidomimetics, particularly in medicinal chemistry research and pharmaceutical development. Its primary application is as a key intermediate in the synthesis of biologically active peptides and small molecule drugs. The incorporation of the 4-fluorophenylalanine residue can modulate the pharmacokinetic properties, metabolic stability, and binding affinity of the target molecules. It is widely used in the development of potential therapeutic agents targeting various diseases. As a Boc-protected amino acid, it offers excellent stability and handling properties for solid-phase peptide synthesis (SPPS) and solution-phase chemistry. The fluorine atom on the aromatic ring introduces unique electronic and steric characteristics, making it a valuable tool for structure-activity relationship (SAR) studies in drug discovery programs.

Physical Properties

Melting Point: 83-86 °C

Boiling Point: 431.2 °C at 760 mmHg

Flash Point: 214.6 °C

Density: 1.216 g/cm3

Storage: Keep Cold

Analytical Data

Appearance: white to light yellow crystal powder