Methyl 4-methoxyacetoacetate, CAS No. 41051-15-4

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41051-15-4

Catalog No. EBD25885

CAS 41051-15-4

Name Methyl 4-methoxyacetoacetate

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Basic Information

Synonyms: methyl4-methoxy-3-oxobutanoate methyl4-methoxy-3-oxobutyrate Methyl-4-methoxyacetoacetate Methyl4-methoxy-3-oxo-butanoate Methyl4-methoxyacetoacetate

Molecular Formula: C6H10O4

Molecular Weight: 146.14

MDL Number: MFCD00010183

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

4-Methoxyacetoacetic acid methyl ester is an organic compound characterized by its molecular structure containing both a methyl ester and a methoxy-substituted acetoacetate moiety. It serves as a versatile β-ketoester building block in organic synthesis. Its primary application is as a key intermediate in the synthesis of various heterocyclic compounds, particularly pyrazoles and pyrimidines. The reactive methylene group flanked by carbonyls makes it a valuable substrate for condensation reactions, such as the Knorr pyrazole synthesis and the synthesis of uracil derivatives. It is also used in the preparation of pharmaceuticals and agrochemicals. This compound is typically handled as a liquid and requires storage under inert conditions due to its sensitivity to moisture and potential for decomposition. It is an important reagent for researchers developing novel chemical entities in medicinal and agricultural chemistry.

Physical Properties

Melting Point: -80℃

Boiling Point: 89 °C/8.5 mmHg(lit.)

Flash Point: 87 °C

Density: 1.129 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.431(lit.)

Analytical Data

Appearance: colorless to yellow liquid