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    40704-11-8

    Catalog No. EBD3078

    CAS 40704-11-8

    Name 3-methyl-1H-pyrazole-4-carboxylic acid

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    Basic Information

    Synonyms: 5-methyl-1H-pyrazole-4-carboxylicacid 1H-Pyrazole-4-carboxylicacid,3-methyl- 1H-pyrazole-4-carboxylicacid,5-methyl- 3-methyl-1H-pyrazole-4-carboxylicacid 3-Methyl-pyrazole-4-carboxylicacid

    Molecular Formula: C5H6N2O2

    Molecular Weight: 126.11

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    3-Methyl-1H-pyrazole-4-carboxylic acid is a heterocyclic carboxylic acid featuring a pyrazole ring substituted with a methyl group at the 3-position and a carboxylic acid group at the 4-position. It serves as a versatile and important building block in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of various pharmaceutical compounds. Notably, it is a crucial precursor in the production of Celecoxib, a widely used nonsteroidal anti-inflammatory drug (NSAID) that functions as a selective cyclooxygenase-2 (COX-2) inhibitor. The pyrazole core is integral to the pharmacophore of this class of drugs. Due to its bifunctional nature (carboxylic acid and heterocyclic NH), it is also employed in the synthesis of other bioactive molecules, agrochemicals, and coordination complexes, making it a valuable reagent in organic synthesis and drug discovery research.
    Physical Properties

    Melting Point: 225-230 °C (dec.)(lit.)

    Boiling Point: 384.2 °C at 760 mmHg

    Flash Point: 186.1 °C

    Density: 1.404 g/cm3

    mg g kg ml l t