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    4068-78-4

    Catalog No. EBD15163

    CAS 4068-78-4

    Name Methyl 5-chloro-2-hydroxybenzoate

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    Basic Information

    Synonyms: methyl5-Chlorosalicylate 5-Chloro-2-hydeoxybenzoicacidmethylester Methyl5-chloro-2-hydroxybenzoate

    Molecular Formula: C8H7ClO3

    Molecular Weight: 186.59

    MDL Number: MFCD00016461

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

    Product Description:
    Methyl 5-chlorosalicylate is an organic compound with the molecular formula C8H7ClO3. It is a methyl ester derivative of 5-chlorosalicylic acid, featuring both a phenolic hydroxyl group and a chloro substituent on the aromatic ring. This structure makes it a versatile bifunctional building block. This compound is primarily used as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly in the development of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents where the salicylate or chlorinated aromatic core is required. Its bifunctionality allows for selective modifications at either the ester or the phenolic group. As a synthetic intermediate, it is also employed in organic research and material science for constructing more complex molecules. Standard safety precautions for handling organic chemicals should be observed, including the use of personal protective equipment due to its potential irritant properties.
    Physical Properties

    Melting Point: 46-50 °C(lit.)

    Boiling Point: 260.5 °C at 760 mmHg

    Flash Point: >230 °F

    Density: 1.354 g/cm3

    mg g kg ml l t