Fmoc-(S)-3-Amino-4-(2-bromophenyl)-butyric acid, CAS No. 403661-79-0

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403661-79-0

Catalog No. EBD3083726

CAS 403661-79-0

Name Fmoc-(S)-3-Amino-4-(2-bromophenyl)-butyric acid

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Basic Information

Synonyms: Fmoc-(S)-3-Amino-4-(2-bromophenyl)-butyricacid Benzenebutanoicacid,2-bromo-b-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,(bS)- FMOC-(S)-3-AMINO-4-(2-BROMOPHENYL)BUTANOICACID FMOC-(S)-3-AMINO-4-(2-BROMO-PHENYL)-BUTYRICACID FMOC-PHE(2-BR)-(C*CH2)OH FMOC-BETA-HOPHE(2-BR)-OH FMOC-2-BROMO-L-BETA-HOMOPHENYLALANINE RARECHEMAKPTF131 (S)-N-(9-FLUORENYLMETHOXYCARBONYL)-3-AMINO-4-(2-BROMO-PHENYL)-BUTYRICACID N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-L-HOMO(2-BROMOPHENYL)ALANINE

Molecular Formula: C25H22BrNO4

Molecular Weight: 480.35

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

Fmoc-(S)-3-amino-4-(2-bromophenyl)butanoic acid is a non-natural, chiral amino acid derivative. Its structure features an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amine, a carboxylic acid functional group, and a side chain containing a 2-bromophenyl moiety. This specific combination of a protected amine, a free acid, and an aromatic bromine substituent makes it a valuable, specialized building block. This compound is primarily employed in solid-phase peptide synthesis (SPPS) as a protected amino acid monomer. The Fmoc group is standard for temporary N-terminal protection in Fmoc-based SPPS strategies, while the free carboxylic acid allows for coupling to the growing peptide chain. The unique 2-bromophenyl side chain can serve multiple purposes: it can act as a handle for further synthetic modification via cross-coupling reactions (e.g., Suzuki, Sonogashira), or it can be incorporated to impart specific conformational or binding properties to the final peptide or peptidomimetic. Its main application is in the research and development of novel bioactive peptides and peptide-based drug candidates.

Physical Properties