2-Fluoro-4-nitrobenzoic acid, CAS No. 403-24-7

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403-24-7

Catalog No. EBD28932

CAS 403-24-7

Name 2-Fluoro-4-nitrobenzoic acid

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Basic Information

Synonyms: 2-Fluoro-4-nitrobenzoicacid 2-FLUORO-4-NITROBENZENECARBOXYLICACID BUTTPARK32\01-74 SALOR-INTL446572-1EA 2-Fluoro-4-nitroBenzoicacid95+% 2-Fluoro-4-nitrobenzotcacid 1-(4-fluorophenyl)-2-hydroxyethanone 2-fluoro-4-nitrobenzoate

Molecular Formula: C7H4FNO4

Molecular Weight: 185.11

MDL Number: MFCD00275565

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

2-Fluoro-4-nitrobenzoic acid is an organic compound featuring a benzoic acid core substituted with a fluorine atom at the 2-position and a nitro group at the 4-position. It serves as a versatile and important aromatic building block in organic synthesis. Its primary application is in the pharmaceutical industry as a key intermediate. The presence of both electron-withdrawing groups (fluoro and nitro) makes it a valuable precursor for the synthesis of various heterocyclic compounds and active pharmaceutical ingredients (APIs). It is notably used in the preparation of benzimidazole derivatives and other nitrogen-containing heterocycles, which are common scaffolds in medicinal chemistry for developing drugs with diverse biological activities. As a bifunctional molecule containing both a carboxylic acid and a reactive aromatic nitro group, it is amenable to a range of chemical transformations, including reduction, nucleophilic aromatic substitution, and amide coupling. This reactivity profile solidifies its role as a fundamental synthetic intermediate in research and development.

Physical Properties

Melting Point: 170 °C

Boiling Point: 352.5 °C at 760 mmHg

Flash Point: 167 °C

Density: 1.568 g/cm3

Analytical Data

Appearance: white to light yellow crystal powder