2-(Diphenylphosphino)-2'-methoxybiphenyl, often referred to as MeO-BIPHEP, is a chiral, atropisomeric bidentate phosphine ligand. Its structure features a biaryl backbone with a diphenylphosphino group and a methoxy group at the ortho positions, creating a specific chiral environment. This compound is typically used as a racemate or can be resolved into its enantiomerically pure forms for asymmetric catalysis. The primary application of MeO-BIPHEP is as a privileged ligand in transition metal-catalyzed asymmetric hydrogenation and other C-C bond-forming reactions. It forms highly effective complexes with metals like ruthenium and rhodium, enabling the synthesis of chiral pharmaceutical intermediates and fine chemicals with high enantioselectivity. Its methoxy substituent fine-tunes the electronic and steric properties, enhancing catalytic performance. Furthermore, derivatives of such phosphine ligands are investigated as components in the synthesis of organometallic complexes for use in organic light-emitting diodes (OLEDs) and other optoelectronic materials. This air-sensitive compound requires handling under an inert atmosphere. It is a valuable tool in both academic research and industrial process development for asymmetric synthesis and advanced material fabrication.