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    40004-69-1

    Catalog No. EBD50566

    CAS 40004-69-1

    Name 2-methyl-1,3-thiazole-5-carboxylic acid

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    Basic Information

    Synonyms: 5-Thiazolecarboxylicacid,2-methyl- 2-Methyl-thiazole-5-carboxylicacid 2-Methylthiazole-5-carboxylicacid 2-methyl-1,3-thiazole-5-carboxylicacid

    Molecular Formula: C5H5NO2S

    Molecular Weight: 143.16

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    2-Methylthiazole-5-carboxylic acid is a heterocyclic carboxylic acid featuring a thiazole ring substituted with a methyl group at the 2-position and a carboxylic acid group at the 5-position. It serves as a versatile and important building block in organic synthesis, particularly in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of various pharmaceutical compounds. Notably, it is a crucial precursor in the production of famotidine, a widely used histamine H2-receptor antagonist for treating gastric ulcers and gastroesophageal reflux disease (GERD). The thiazole core is a privileged scaffold in drug discovery, contributing to the biological activity of the final molecules. This compound is commercially available from chemical suppliers specializing in fine chemicals and pharmaceutical intermediates. It is typically handled as a solid and requires standard laboratory safety precautions for handling carboxylic acids and heterocyclic compounds.
    Physical Properties

    Boiling Point: 301.2 °C at 760 mmHg

    Flash Point: 136 °C

    Density: 1.418 g/cm3

    mg g kg ml l t