1-Fluoro-4-nitro-2-(trifluoromethyl)benzene, CAS No. 400-74-8

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400-74-8

Catalog No. EBD14013

CAS 400-74-8

Name 1-Fluoro-4-nitro-2-(trifluoromethyl)benzene

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Basic Information

Synonyms: 2-Fluoro-5-nitrobenzotrifluoride 2-fluoro-5-nitro-α,α,α-trifluorotoluene 1,7-dimethylnaphthalene

Molecular Formula: C7H3F4NO2

Molecular Weight: 209.1

MDL Number: MFCD00024576

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

2-Fluoro-5-nitrobenzotrifluoride is an organic compound characterized by a benzene ring substituted with a trifluoromethyl group, a nitro group, and a fluorine atom. It serves as a versatile and valuable fluorinated aromatic building block in synthetic organic chemistry. Its primary utility lies in its role as a key intermediate for the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. The presence of both electron-withdrawing groups (nitro and trifluoromethyl) and a halogen (fluorine) makes it amenable to various nucleophilic aromatic substitution and cross-coupling reactions. It is frequently used to introduce the 2-fluoro-5-(trifluoromethyl)aniline moiety into target structures. This compound is a solid at room temperature and requires careful handling due to its potential irritant properties. It is commonly sourced from chemical suppliers for laboratory-scale synthesis and process development.

Physical Properties

Melting Point: 22-24°C

Boiling Point: 105-110 °C/25 mmHg(lit.)

Flash Point: 92 °C

Density: 1.522 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.465(lit.)

Analytical Data

Appearance: clear yellowish liquid