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    399-51-9

    Catalog No. EBD971612

    CAS 399-51-9

    Name 6-Fluoroindole

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    Basic Information

    Synonyms: 6-Fluoroindole 6-Fluoro-1H-indole

    Molecular Formula: C8H6FN

    Molecular Weight: 135.14

    MDL Number: MFCD00056933

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    6-Fluoroindole is a heterocyclic aromatic organic compound with the molecular formula C8H6FN. It is a derivative of indole where a fluorine atom is substituted at the 6-position of the benzene ring. This compound is a pale yellow to brown solid or crystalline powder and serves as a versatile building block in organic synthesis. Its primary and most significant application is as a key pharmaceutical intermediate. The fluorine atom can significantly alter the biological activity, metabolic stability, and lipophilicity of drug molecules. 6-Fluoroindole is widely used in the research and development of various bioactive compounds, including potential drugs targeting the central nervous system, anti-inflammatory agents, and antimicrobial agents. It is a crucial precursor for synthesizing more complex indole-based structures. As a fluorinated heterocycle, it is also a valuable synthon in material science and agrochemical research. Its reactivity allows for further functionalization, making it a common starting point for constructing complex molecular architectures in medicinal and synthetic chemistry.
    Physical Properties

    Melting Point: 72-76 °C(lit.)

    Boiling Point: 258 °C at 760 mmHg

    Flash Point: 109.9 °C

    Density: 1.273 g/cm3

    Solubility: insoluble in water

    Storage: 2-8°C

    Analytical Data

    Appearance: Beige-brown crystalline powder

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