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    397246-14-9

    Catalog No. EBD13570

    CAS 397246-14-9

    Name (R)-(+)-2-(Boc-Amino)-1,4-butanediol

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    Basic Information

    Synonyms: (2R)-(tert-Butoxycarbonylamino)butane-1,4-diol [(1R)-3-Hydroxy-1-(hydroxymethyl)propyl]carbamicacidtert-butylester (R)-(+)-2-(Boc-Amino)-1,4-butanediol tert-butyl[(2R)-1,4-dihydroxybutan-2-yl]carbamate

    Molecular Formula: C9H19NO4

    Molecular Weight: 205.25

    MDL Number: MFCD08703679

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-(+)-2-(Boc-Amino)-1,4-butanediol is a chiral organic compound featuring a 1,4-butanediol backbone with a Boc-protected amino group at the chiral (R)-configured 2-position. It serves as a versatile chiral building block in organic synthesis, particularly valued for its two hydroxyl groups and a protected amine, which allow for selective functionalization. This compound is primarily employed in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its chiral structure makes it a key precursor in the development of drugs targeting the central nervous system, antiviral agents, and other bioactive molecules where stereochemistry is critical for efficacy. The Boc protecting group facilitates further synthetic manipulations under mild conditions. As a bifunctional chiral synthon, it is widely used in medicinal chemistry research for constructing peptidomimetics and other pharmacologically relevant scaffolds. Its applications extend to materials science for creating chiral polymers or ligands. Standard precautions for handling amines and alcohols should be observed in the laboratory.
    Physical Properties

    Melting Point: 64-68 °C

    Boiling Point: 365.041 °C at 760 mmHg

    Flash Point: 174.571 °C

    Density: 1.11 g/cm3

    mg g kg ml l t