5-Chloro-2-fluorobenzoic acid, CAS No. 394-30-9

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394-30-9

Catalog No. EBD24514

CAS 394-30-9

Name 5-Chloro-2-fluorobenzoic acid

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Basic Information

Synonyms: 5-Chloro-2-fluorobenzoicacid BUTTPARK14\01-27 RARECHEMALBO0944 5-CHLORO-2-FLUOROBENZOICACI 2-Fluoro-5-ChlorobenzoicAcid 5-Chloro-2-Fluorobenzoic 5-chloro-2-fluorobenzoate

Molecular Formula: C7H4ClFO2

Molecular Weight: 174.56

MDL Number: MFCD00665762

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

5-Chloro-2-fluorobenzoic acid is a halogenated benzoic acid derivative with the molecular formula C7H4ClFO2. It features both chlorine and fluorine substituents on the aromatic ring, along with a carboxylic acid functional group, making it a versatile building block in organic synthesis. This compound is primarily utilized as a key intermediate in the pharmaceutical industry for the synthesis of various drug molecules, particularly those targeting the central nervous system and anti-inflammatory pathways. Its specific substitution pattern allows for further functionalization, such as amide bond formation or cross-coupling reactions, to construct more complex active pharmaceutical ingredients (APIs). As a synthetic building block, it falls under the category of halogenated aromatics, which are fundamental for transition-metal-catalyzed coupling reactions like Suzuki or Buchwald-Hartwig aminations. Its dual halogenation provides unique reactivity and selectivity in medicinal chemistry programs.

Physical Properties

Melting Point: 152-157 °C(lit.)

Boiling Point: 274.7 °C at 760 mmHg

Flash Point: 120 °C

Density: 1.477 g/cm3