(R)-tert-Butyl methyl(pyrrolidin-3-yl)carbamate, CAS No. 392338-15-7

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392338-15-7

Catalog No. EBD2222495

CAS 392338-15-7

Name (R)-tert-Butyl methyl(pyrrolidin-3-yl)carbamate

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Basic Information

Synonyms: (R)-tert-Butylmethyl(pyrrolidin-3-yl)carbamate tert-butylmethyl[(3R)-pyrrolidin-3-yl]carbamate Carbamicacid,N-methyl-N-[(3R)-3-pyrrolidinyl]-,1,1-dimethylethylester tert-butylN-methyl-N-[(3R)-pyrrolidin-3-yl]carbamate

Molecular Formula: C10H20N2O2

Molecular Weight: 200.28

MDL Number: MFCD09263387

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-3-(N-Boc-N-methylamino)pyrrolidine is a chiral, N-Boc and N-methyl protected pyrrolidine derivative. It serves as a versatile chiral building block and intermediate in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). A prominent example is its use in the synthesis of TAK-875 (Fasiglifam), a GPR40 agonist that was investigated for the treatment of type 2 diabetes. The chiral pyrrolidine core is a crucial structural motif in this and other drug candidates, imparting specific three-dimensional interactions with biological targets. The compound is commercially available from suppliers specializing in fine chemicals and chiral intermediates for medicinal chemistry. It is typically handled under inert atmosphere and stored at low temperatures (e.g., 2-8°C) due to the sensitivity of the Boc protecting group.

Physical Properties

Boiling Point: 268.3°C at 760 mmHg

Flash Point: 116°C

Density: 1.03g/cm3