Tert-Butyl (cis-3-hydroxycyclobutyl)carbamate is a chiral cyclobutane derivative featuring both a protected amine (as a Boc carbamate) and a free hydroxyl group. This specific cis-stereochemistry is a key structural motif. It serves as a versatile and important building block in medicinal chemistry, particularly for the synthesis of complex bioactive molecules. Its primary application is as a key synthetic intermediate in the development of pharmaceutical compounds. The molecule is notably used in the research and synthesis of KRAS G12C inhibitors, a prominent class of targeted anti-cancer drugs. The cis-3-aminocyclobutanol scaffold it provides is a critical structural component for binding to the target protein. The Boc protecting group allows for selective manipulation of the amine functionality during multi-step synthetic sequences. This compound is commercially available from suppliers specializing in advanced pharmaceutical intermediates and fine chemicals for drug discovery. It exemplifies the use of constrained, three-dimensional scaffolds to improve the drug-like properties of candidate molecules, such as binding affinity and metabolic stability.