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    389889-62-7

    Catalog No. EBD2784

    CAS 389889-62-7

    Name t-butyl (3R)-3-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate

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    Basic Information

    Synonyms: (R)-1-N-Boc-3-(2-hydroxyethyl)piperidine (R)-tert-Butyl3-(2-hydroxyethyl)piperidine-1-carboxylate (R)-3-(2-Hydroxyethyl)piperidine-1-carboxylicacidtert-butylester tert-butyl(3R)-3-(2-hydroxyethyl)piperidine-1-carboxylate t-butyl(3R)-3-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate

    Molecular Formula: C12H23NO3

    Molecular Weight: 229.32

    MDL Number: MFCD06796567

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    This compound is a chiral piperidine derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the nitrogen atom and a 2-hydroxyethyl substituent at the 3-position. This compound is a versatile and valuable building block in organic synthesis, particularly in medicinal chemistry. Its primary application is as a key chiral intermediate in the synthesis of various pharmaceutical agents. The presence of the Boc group allows for selective deprotection under mild acidic conditions, enabling further functionalization of the nitrogen atom. The hydroxymethyl side chain can be readily oxidized to an aldehyde or carboxylic acid, or used in ether/ester formation, providing a handle for molecular diversification. This scaffold is frequently employed in the development of central nervous system (CNS) drugs, enzyme inhibitors, and other bioactive molecules that require a chiral piperidine core. The compound is commercially available from suppliers specializing in fine chemicals and chiral building blocks for drug discovery. It is typically handled under inert atmosphere and stored at low temperatures to ensure stability.
    Physical Properties

    Boiling Point: 324.1 °C at 760 mmHg

    Flash Point: 149.8 °C

    Density: 1.043 g/cm3

    mg g kg ml l t