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    38875-53-5

    Catalog No. EBD583201

    CAS 38875-53-5

    Name 2,3-Diamino-5-bromopyridine

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    Basic Information

    Synonyms: 5-Bromopyridine-2,3-diamine 2,3-diamino-5-bromopyridinium 2,3-Diamino-5-bromopyridine 5-Bromo-2,3-diaminopyridine 5-bromo-2,3-pyridinediamine pyridine,2,3-diamino-5-bromo-(6ci,7ci)

    Molecular Formula: C5H6BrN3

    Molecular Weight: 188.03

    MDL Number: MFCD00460094

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    5-Bromo-2,3-diaminopyridine is a heterocyclic aromatic compound featuring a pyridine ring substituted with a bromine atom at the 5-position and two amino groups at the 2- and 3-positions. This bifunctional molecule serves as a versatile and valuable building block in organic synthesis, particularly in the construction of complex nitrogen-containing heterocycles. Its primary and most significant application is in the pharmaceutical industry as a key intermediate for the synthesis of various active pharmaceutical ingredients (APIs). The compound is notably used in the preparation of kinase inhibitors, such as certain JAK (Janus kinase) inhibitors, which are important for treating autoimmune diseases and cancers. The presence of both a halogen (bromine) and two nucleophilic amino groups allows for sequential and regioselective functionalization, enabling the efficient assembly of fused heterocyclic systems like imidazo[4,5-b]pyridines, which are common pharmacophores in drug discovery. As a synthetic intermediate, it is also employed in materials science research, particularly for creating ligands in coordination chemistry or precursors for functional organic materials. Standard safety precautions for handling amines and halogenated compounds should be observed.
    Physical Properties

    Melting Point: 155 °C (dec.)(lit.)

    Boiling Point: 320.9 °C at 760 mmHg

    Flash Point: 147.9 °C

    Density: 1.818 g/cm3

    Solubility: soluble in hot water

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