4-methylumbellifenyl ±-D-galactopyranoside, CAS No. 38597-12-5

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38597-12-5

Catalog No. EBD730747

CAS 38597-12-5

Name 4-methylumbellifenyl ±-D-galactopyranoside

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Basic Information

Synonyms: 7-(α-D-galactopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one 4-methylumbellifenyl±-D-galactopyranoside 4-methylumberriferyl-±-D-galactopyranoside 4-methylumbelliferyl-±-D-galactoside 7-±-D-galactopyranosyloxy-4-methyl-coumarin 7-±-D-Galactopyranosyloxy-4-methyl-cumarin 7-(±-D-galactopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one 4-methylumbelliferyl-±-D-galactopyranoside

Molecular Formula: C16H18O8

Molecular Weight: 338.31

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > In Vitro Diagnostic (IVD) Reagents Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

4-Methylumbelliferyl α-D-glucopyranoside (4-MU-α-Glc, CAS 38597-12-5) is a fluorogenic substrate widely used in biochemical and clinical research. It is a glycosidic conjugate where 4-methylumbelliferone (a fluorescent molecule) is linked to α-D-glucopyranoside. The compound itself exhibits minimal fluorescence, but upon enzymatic hydrolysis of the glycosidic bond by specific α-glucosidases, it releases the highly fluorescent 4-methylumbelliferone. Its primary application is as a sensitive and specific substrate for the detection and quantification of α-glucosidase enzyme activity. This is crucial in various fields, including the diagnosis of genetic disorders like Pompe disease (acid α-glucosidase deficiency), screening for diabetes management drugs that inhibit α-glucosidase, and general enzymatic studies in microbiology and plant biology. The assay is performed by monitoring the increase in fluorescence intensity over time, which is directly proportional to the enzyme activity. Due to its role as a critical tool in enzymatic diagnostics and research, it is classified as a biochemical reagent. It is not typically used as a general synthetic building block or in material science applications, but rather as a specialized probe in life sciences.

Physical Properties

Melting Point: 171-173 °C

Boiling Point: 626.9 °C at 760 mmHg

Flash Point: 233.9 °C

Density: 1.522 g/cm3

Solubility: H2O: 10 mg/mL hot, clear, colorless

Storage: −20°C

Analytical Data

Appearance: white to almost white crystalline powder