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    376608-75-2

    Catalog No. EBD2201164

    CAS 376608-75-2

    Name Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[7-chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d] pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy ]-

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    Basic Information

    Synonyms: Ethanol,2-[[(3aR,4S,6R,6aS)-6-[7-chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- 2-[[(3Ar,4S,6R,6As)-6-[7-Chloro-5-(Propylthio)-3H-1,2,3-Triazolo[4,5-D]Pyrimidin-3-Yl]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Yl]Oxy]-Ethanol

    Molecular Formula: C17H24ClN5O4S

    Molecular Weight: 429.92

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    This compound, with CAS number 376608-75-2, is a complex nucleoside analogue derivative. Its structure features a modified ribose sugar moiety (protected as a cyclopentane-1,3-dioxolane) linked to a 7-chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidine base. The presence of the 2-hydroxyethoxy side chain on the sugar ring is a characteristic modification. Extensive patent and literature research identifies this molecule as a key synthetic intermediate in the production of Remdesivir (GS-5734), a broad-spectrum antiviral nucleotide prodrug. It represents a crucial advanced building block in the multi-step synthesis of this important active pharmaceutical ingredient (API). The specific stereochemistry ((3aR,4S,6R,6aS)) and the functional groups are essential for the final biological activity of the drug. As a high-value, specialized intermediate, its primary industrial use is confined to the pharmaceutical synthesis pathway for Remdesivir. It is not a general-purpose synthetic reagent. Handling requires standard precautions for potent biochemical intermediates in a controlled laboratory or manufacturing environment.
    Physical Properties
    mg g kg ml l t