Ethyl pyrazole-4-carboxylate, CAS No. 37622-90-5

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37622-90-5

Catalog No. EBD23080

CAS 37622-90-5

Name Ethyl pyrazole-4-carboxylate

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Basic Information

Synonyms: Ethylpyrazole-4-carboxylate ethyl1H-pyrazole-4-carboxylate 1H-pyrazol-4-ylpropanoate 1H-Pyrazole-4-carboxylicacidethylester Ethyl4-pyarazolecarboxylate 4-(C2H5COO)-pyrazole Ethyl 1H-pyrazole-4-carboxylate

Molecular Formula: C6H8N2O2

Molecular Weight: 140.14

MDL Number: MFCD00010844

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Ethyl 4-pyrazolecarboxylate is an organic compound featuring a pyrazole ring substituted with an ester functional group at the 4-position. It serves as a versatile heterocyclic building block in organic synthesis. Its primary application is in the pharmaceutical industry as a key intermediate for the synthesis of various bioactive molecules. Notably, it is a crucial precursor in the production of COX-2 inhibitors, such as celecoxib and related derivatives, which are nonsteroidal anti-inflammatory drugs (NSAIDs). The pyrazole core is a privileged scaffold in medicinal chemistry, and this specific ester derivative allows for further functionalization to create targeted drug candidates. As a readily available and modifiable synthon, it is widely used in research and development for constructing complex heterocyclic systems with potential biological activity.

Physical Properties

Melting Point: 78-80 °C(lit.)

Boiling Point: 138-140 °C/3 mmHg(lit.)

Flash Point: 138-140°C/3mm

Density: 1.214 g/cm3