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    3721-28-6

    Catalog No. EBD3330636

    CAS 3721-28-6

    Name 2-phenyl-, (1S,2R)-cyclopropanamine

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    Basic Information

    Synonyms: 2-phenyl-,(1S,2R)-cyclopropanamine Cyclopropanamine,2-phenyl-,(1S,2R)- Cyclopropanamine,2-phenyl-,(1S-trans)- ((1S,2R)-2-Phenylcyclopropyl)amine (+)-Tranylcypromine (+)-trans-2-Phenylcyclopropylamine (1S,2R)-2-Phenylcyclopropanamine (1S,2R)-Tranylcypromine (1S-trans)-2-Phenylcyclopropylamine 1-(S)-Amino-2-(R)-phenylcyclopropane d-Tranylcypromine

    Molecular Formula: C9H11N

    Molecular Weight: 133.19

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (1S,2R)-2-Phenylcyclopropanamine is a chiral amine compound featuring a cyclopropane ring substituted with a phenyl group and an amino group. It is a key chiral building block in organic synthesis, particularly valued for its rigid, strained three-membered ring structure which can impart unique conformational and biological properties to target molecules. Its primary and most significant application is as a crucial intermediate in the pharmaceutical industry for the synthesis of various active pharmaceutical ingredients (APIs). It serves as a core structural motif in the development of drugs targeting the central nervous system, including antidepressants and anticonvulsants. The specific stereochemistry of the (1S,2R) enantiomer is often essential for achieving the desired biological activity and selectivity in these drug candidates. Beyond its pharmaceutical applications, this compound is also utilized in academic and industrial research as a versatile chiral synthon for constructing complex molecules. Its availability in enantiomerically pure form makes it a valuable tool for asymmetric synthesis and medicinal chemistry programs exploring novel chemical space.
    Physical Properties

    Boiling Point: 218.3°Cat760mmHg

    Flash Point: 90.8°C

    mg g kg ml l t