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    3685-22-1

    Catalog No. EBD2332983

    CAS 3685-22-1

    Name cis-4-Hydroxycyclohexane carboxylic acid

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    Basic Information

    Synonyms: cis-4-Hydroxycyclohexanecarboxylicacid cyclohexanecarboxylicacid,4-hydroxy-,cis-

    Molecular Formula: C7H12O3

    Molecular Weight: 144.17

    Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

    Product Description:
    Cis-4-Hydroxycyclohexane carboxylic acid is a chiral, non-aromatic cyclic compound featuring a cyclohexane ring with a hydroxyl group and a carboxylic acid group in a cis configuration. This specific stereochemistry makes it a valuable building block in asymmetric synthesis. Its primary application is as a key chiral intermediate in the pharmaceutical industry. It is extensively used in the synthesis of various biologically active molecules, including drugs targeting the central nervous system (e.g., GABA analogs like Gabapentin and Pregabalin precursors) and other therapeutic areas where the rigid cyclohexane scaffold imparts specific conformational properties to the drug molecule. As a synthetic building block, it serves as a versatile precursor for further functionalization. The hydroxyl and carboxyl groups can be independently protected, activated, or transformed into esters, amides, or ethers, allowing for the construction of complex molecular architectures in medicinal chemistry and organic synthesis.
    Physical Properties

    Melting Point: 150 °C

    Boiling Point: 307.898 °C at 760 mmHg

    Flash Point: 154.234 °C

    Density: 1.246 g/cm3

    Safety Information

    Packing Level: III

    Hazard Category: 6.1

    Transport Codes: 2811

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