5-Fluoro-2-methylaniline, CAS No. 367-29-3

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367-29-3

Catalog No. EBD44282

CAS 367-29-3

Name 5-Fluoro-2-methylaniline

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Basic Information

Synonyms: 5-Fluoro-2-methylaniline 5-Fluoro-o-toluidine Fluoromethylaniline 2-Amino-4-fluorotoluene 4-Fluoro-2-Aminotoluene 2-Methyl-5-Fluoroaniline

Molecular Formula: C7H8FN

Molecular Weight: 125.14

MDL Number: MFCD00007764

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

5-Fluoro-2-methylaniline is an aromatic amine derivative characterized by a fluorine substituent at the 5-position and a methyl group at the 2-position relative to the amino group. It serves as a versatile and important building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). It is notably used in the production of selective serotonin reuptake inhibitors (SSRIs) and other central nervous system (CNS) agents. The fluorine atom and the methyl group on the aniline ring are crucial structural motifs that influence the biological activity, metabolic stability, and binding affinity of the final drug molecules. As a substituted aniline, it is a common starting material for constructing more complex heterocyclic systems and functionalized aromatic compounds through reactions such as diazotization, amide formation, and nucleophilic substitution.

Physical Properties

Melting Point: 38-40 °C(lit.)

Boiling Point: 98-100°C 15mm

Flash Point: 90 °C

Density: 1.115 g/cm3

Solubility: insoluble

Refractivity: 1.538