4-Bromo-2-fluoroaniline, CAS No. 367-24-8

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367-24-8

Catalog No. EBD1100589

CAS 367-24-8

Name 4-Bromo-2-fluoroaniline

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Basic Information

Synonyms: 2-Fluoro-4-Bromoaniline 4-bromo-2-fluorobenzenamine Bromofluoroaniline4 4-Bromo-2-fluoroaniline -bromo-2-fluoroaniline 4-bromo-2-fluoro-aniline benzenamine,4-bromo-2-fluoro-

Molecular Formula: C6H5BrFN

Molecular Weight: 190.01

MDL Number: MFCD00010221

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

4-Bromo-2-fluoroaniline is a bifunctional aromatic building block featuring a primary amino group, a bromine atom, and a fluorine substituent on a benzene ring. Its molecular formula is C6H5BrFN, with a molecular weight of 190.01 g/mol. The presence of both halogen and amine functionalities makes it a versatile intermediate for cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations. This compound is primarily utilized as a key intermediate in the synthesis of pharmaceutical agents, particularly in the development of kinase inhibitors and other small-molecule drugs targeting oncology and inflammatory diseases. The fluorine atom enhances metabolic stability and binding affinity, while the bromine serves as a handle for further functionalization. It is also employed in agrochemical research for constructing bioactive molecules. As a common synthetic building block, it is widely used in medicinal chemistry and organic synthesis laboratories for constructing complex heterocycles and drug-like scaffolds. Standard safety precautions should be observed due to its potential irritant properties.

Physical Properties

Melting Point: 40-42 °C

Boiling Point: 103-108 °C (13 mmHg)

Flash Point: 104 °C

Density: 1.694 g/cm3

Analytical Data

Appearance: solid