Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    364-73-8

    Catalog No. EBD34000

    CAS 364-73-8

    Name 4-Bromo-1-fluoro-2-nitrobenzene

    Get Quote
    Basic Information

    Synonyms: 5-bromo-2-fluoronitrobenzene 4-BROMO-1-FLUORO-2-NITROBENZENE 1-BROMO-4-FLUORO-3-NITROBENZENE 5-Bromo-2-fluoronitrobenzene98%

    Molecular Formula: C6H3BrFNO2

    Molecular Weight: 220.0

    MDL Number: MFCD00129165

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    5-Bromo-2-fluoronitrobenzene is an aromatic compound featuring a nitro group, a bromine atom, and a fluorine atom on a benzene ring. It serves as a versatile and important multi-functionalized building block in organic synthesis. The presence of three distinct reactive sites (nitro, bromo, and fluoro) allows for sequential and selective chemical transformations, making it a key intermediate for constructing complex molecules. Its primary application is in the pharmaceutical industry as a crucial intermediate for the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates. It is notably used in the preparation of substituted anilines, benzimidazoles, and other nitrogen-containing heterocycles, which are common scaffolds in medicinal chemistry. The compound is also employed in materials science research for the synthesis of functionalized aromatic systems. As a halogenated nitroarene, it requires careful handling due to potential toxicity and irritant properties. It is typically used under controlled conditions in laboratory and industrial settings for cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to access valuable pharmacophores.
    Physical Properties

    Melting Point: 18-19 °C(lit.)

    Boiling Point: 240-241 °C(lit.)

    Flash Point: >110 °C

    Density: 1.786 g/mL at 25 °C(lit.)

    Refractivity: n20/D 1.575(lit.)

    Analytical Data

    Appearance: clear yellow to brownish liquid after melting

    mg g kg ml l t