N-Boc-hydroxylamine, CAS No. 36016-38-3

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

36016-38-3

Catalog No. EBD968981

CAS 36016-38-3

Name N-Boc-hydroxylamine

Get Quote

Basic Information

Synonyms: tert-ButylN-hydroxycarbamate N-Bochydroxylamine tert-butylhydroxycarbamate N-Boc-hydroxylamine t-ButylN-hydroxycarbomate

Molecular Formula: C5H11NO3

Molecular Weight: 133.15

MDL Number: MFCD00002107

Categories: Synthetic Chemistry > Basic Synthetic Reagents > Protecting and Deprotecting Reagents Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Boc-hydroxylamine is a chemical compound featuring a tert-butoxycarbonyl (Boc) protecting group attached to a hydroxylamine moiety. It is a white to off-white crystalline solid, serving as a stable and versatile synthetic building block. Its primary application is as a protected hydroxylamine reagent in organic synthesis. The Boc group allows for the selective introduction of the hydroxylamine functionality into complex molecules, which is crucial for constructing hydroxamic acids, oximes, and N-alkoxyamines. These structural motifs are frequently found in pharmaceuticals, particularly as key intermediates for histone deacetylase (HDAC) inhibitors and other bioactive compounds. In medicinal chemistry, it is used as a small molecule fragment for building drug-like libraries. Additionally, N-Boc-hydroxylamine is a standard reagent for the protection and deprotection of amine groups in peptide and carbohydrate chemistry. Its stability under basic conditions and ease of removal under mild acidic conditions make it a preferred choice for multi-step synthetic pathways.

Physical Properties

Melting Point: 53-55 °C(lit.)

Boiling Point: 250.4 °C at 760 mmHg

Flash Point: 105.2 °C

Density: 1.101 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: White to light pink crystalline powder