(-)-10-CSA, CAS No. 35963-20-3

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35963-20-3

Catalog No. EBD2204293

CAS 35963-20-3

Name (-)-10-CSA

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Basic Information

Synonyms: (1R)-(-)-camphor-10-sulfonicacid (-)-10-CSA 1R-(-)-Camphorsulfonicacid (1R)-(-)-10-Camphorsulfonicacid L-(-)-camphoursulfoniceacid L(-)-10-Camphorsulfonicacid (1R)-(-)camphorsulfonicacid (-)-camphor-10-sulfonicacid R(-)Camphorsulfonicacid L-(-)Camphor-10-SulfonicAcid L(-)-Camphorsulfonicacid (1R)-(7,7-Dimethyl-2-oxobicyclo(2.2.1)hept-1-yl)methanesulphonicacid (7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonicacid 4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-2-sulfonicacid [(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonicacid (7,7-dimethyl-2-oxo-norbornan-1-yl)methanesulfonicacidhydrate 1R-(-)-Camphor-10-sulfonicacid L-Camphorsulfonicacid L-(+)-CamphorsulfonicAcid Camporsulfornicacid

Molecular Formula: C10H16O4S

Molecular Weight: 232.3

MDL Number: MFCD00064158

Categories: Medicinal Chemistry > Pharmaceutical Excipients > Isotonic Agents, pH Adjusters, and Buffers Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

Product Description:

L-(-)-Camphorsulfonic acid is a chiral organic acid derived from camphor. It is a white to off-white crystalline powder that is highly soluble in water and polar organic solvents. Its structure features a rigid bicyclic framework with a sulfonic acid group, making it a strong, non-hygroscopic acid. Its primary and most significant application is in the pharmaceutical industry as a chiral resolving agent. It is extensively used to separate enantiomers of amines, amino alcohols, and other basic compounds via diastereomeric salt formation. This makes it a critical tool in the production of enantiomerically pure active pharmaceutical ingredients (APIs). Additionally, it serves as an efficient and recyclable chiral Brønsted acid catalyst in various asymmetric organic synthesis reactions, such as the Pictet–Spengler reaction and Mukaiyama aldol reactions. Beyond its role in synthesis and resolution, L-(-)-CSA is also utilized as an acid catalyst in polymerizations (e.g., for conductive polyaniline) and as a component in electrochemical applications. It is generally considered a stable and versatile reagent, though standard safety precautions for handling strong acids should be observed.

Physical Properties

Melting Point: 198 °C (dec.)(lit.)

Density: 1.331 g/cm3

Solubility: soluble

Refractivity: -21.5 ° (C=5, H2O)

Storage: 2-8°C

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3261