NBI 42902, CAS No. 352290-60-9

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

352290-60-9

Catalog No. EBD365244

CAS 352290-60-9

Name NBI 42902

Get Quote

Basic Information

Synonyms: 2,4(1H,3H)-Pyrimidinedione,3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl- NBI42902 3-[(2R)-amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-6-methyl-5-(2-fluoro-3-methoxyphenyl)pyrimidin-2,4-dione 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil NBI-42902 3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2,6-difluorobenzyl]-6-methyl-pyrimidine-2,4-(1H,3H)-dione 3-[(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2,6-difluorobenzyl]-6-methyl-pyrimidine-2,4(1H,3H)-dione 3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2,6-difluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Molecular Formula: C27H24F3N3O3

Molecular Weight: 495.5

Categories: Medicinal Chemistry > APIs and Their Salts > Endocrine & Metabolic Drugs Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

NBI 42902 is a potent and selective non-peptide antagonist of the human gonadotropin-releasing hormone (GnRH) receptor. Its chemical structure is based on a thieno[2,3-b]pyridine core, distinguishing it from earlier peptide-based antagonists. It was developed as a potential therapeutic agent for the treatment of sex hormone-dependent conditions, such as endometriosis, uterine fibroids, and prostate cancer, by blocking the action of GnRH and subsequently suppressing the production of sex steroids. The compound exhibits high binding affinity for the human GnRH receptor and demonstrates significant efficacy in preclinical models. Research on NBI 42902 has contributed to the understanding of non-peptide GnRH antagonist design and has served as a lead structure for further drug development in the field of reproductive endocrinology.

Physical Properties