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    352276-28-9

    Catalog No. EBD8171

    CAS 352276-28-9

    Name Latanoprost Lactol

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    Basic Information

    Synonyms: (3aR,4R,5R,6aS)-Hexahydro-4-[(3R)-3-hydroxy-5-phenylpentyl]-2H-cyclopenta[b]furan-2,5-diol LatanoprostLactol

    Molecular Formula: C18H26O4

    Molecular Weight: 306.4

    Categories: Medicinal Chemistry > APIs and Their Salts > Other Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

    Product Description:
    Latanoprost hemialdehyde is a key synthetic intermediate in the production of latanoprost, a prostaglandin F2α analogue. It is a chiral compound containing a cyclopentane ring and an aldehyde functional group, which serves as a crucial handle for further chemical modifications to construct the final active pharmaceutical ingredient (API). This intermediate is specifically used in the synthesis of latanoprost, a widely prescribed topical medication for the treatment of glaucoma and ocular hypertension. The aldehyde group in the hemialdehyde intermediate is typically subjected to a Wittig or Horner-Wadsworth-Emmons reaction to introduce the necessary omega chain, ultimately forming the prostaglandin structure. Its production and purity are critical for ensuring the efficacy and safety of the final drug product. As a specialized chiral building block, it is not a general-purpose synthetic reagent. Its entire value and application are defined by its role in the manufacture of a specific ophthalmic drug, placing it firmly within the pharmaceutical chemistry domain.
    Physical Properties

    Density: 1.207

    mg g kg ml l t