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    351360-61-7

    Catalog No. EBD30129

    CAS 351360-61-7

    Name tert-Butyl (3S,4R)-4-phenylpyrrolidin-3-ylcarbamate

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    Basic Information

    Synonyms: carbamicacid,N-[(3S,4R)-4-phenyl-3-pyrrolidinyl]-,1,1-dimethylethylester tert-Butyl[(3S,4R)-4-phenylpyrrolidin-3-yl]carbamate tert-Butyl(3S,4R)-4-phenylpyrrolidin-3-ylcarbamate trans-N-Boc-4-phenylpyrrolidin-3-amine

    Molecular Formula: C15H22N2O2

    Molecular Weight: 262.35

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (3S,4R)-4-Phenylpyrrolidin-3-yl tert-butylcarbamate is a chiral pyrrolidine derivative characterized by a trans configuration at the 3 and 4 positions of the heterocyclic ring. It features a phenyl substituent at the 4-position and a tert-butyloxycarbonyl (Boc) protected amine group at the 3-position. This specific stereochemistry is crucial for its application in asymmetric synthesis. This compound serves as a key chiral building block in pharmaceutical research and development. Its primary application is as a versatile intermediate in the synthesis of biologically active molecules, particularly those targeting the central nervous system. The rigid pyrrolidine scaffold with defined stereocenters is a privileged structure found in many drug candidates, including potential inhibitors of enzymes like dipeptidyl peptidase IV (DPP-4) for diabetes treatment and other therapeutic agents. The Boc-protected amine functionality allows for selective deprotection and further derivatization, making it a valuable synthon for constructing complex molecular architectures. Its use is documented in patent literature related to the preparation of medicinally relevant compounds.
    Physical Properties
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