3-Fluoro-4-chlorophenol, CAS No. 348-60-7

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348-60-7

Catalog No. EBD217614

CAS 348-60-7

Name 3-Fluoro-4-chlorophenol

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Basic Information

Synonyms: 3-Fluoro-4-chlorophenol 4-Chloro-3-fluorophenol 4-chloro-3-fluoro-phenol 4-Chlor-3-fluor-phenol Phenol,4-chloro-3-fluoro- QRDGCF 348-60-7

Molecular Formula: C6H4ClFO

Molecular Weight: 146.55

MDL Number: MFCD00042583

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

4-Chloro-3-fluorophenol is an organic compound featuring a phenol ring substituted with chlorine and fluorine atoms at the 4- and 3- positions, respectively. It is a halogenated phenol derivative that serves as a versatile building block in organic synthesis. Its primary application is as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. The presence of both chlorine and fluorine atoms makes it a valuable precursor for introducing these halogens into more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and herbicides. For instance, it is used in the synthesis of certain antibacterial agents and selective herbicides. The compound is a solid at room temperature and requires careful handling due to the potential toxicity and irritant properties common to many halogenated phenols. It is typically used in controlled laboratory and industrial settings for further chemical transformations.

Physical Properties

Melting Point: 54-56 °C(lit.)

Boiling Point: 84 °C/44 mmHg(lit.)

Flash Point: 113 °C

Density: 1.408 g/cm3

Solubility: slightly soluble in water

Analytical Data

Appearance: White to salmon crystalline solid