p-Nitrophenyl-2-acetamido-2-deoxy-β-D-glucopyranosid, CAS No. 3459-18-5

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3459-18-5

Catalog No. EBD2203613

CAS 3459-18-5

Name p-Nitrophenyl-2-acetamido-2-deoxy-β-D-glucopyranosid

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Basic Information

Synonyms: Xanthosin p-Nitrophenyl-2-acetamido-2-deoxy-β-D-glucopyranosid 4'-nitrophenyl-2-acetamido-2-deoxy-β-glucopyranoside 4-nitrophenyl-N-acetyl-β-D-glucosaminide

Molecular Formula: C15H20N2O8

Molecular Weight: 356.33

MDL Number: MFCD00063696

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Biochemicals and Life Science Reagents > In Vitro Diagnostic (IVD) Reagents

Product Description:

4-Nitrophenyl N-acetyl-β-D-glucosaminide is a chromogenic substrate widely used in biochemical and clinical research. It is a synthetic glycoside derivative where 4-nitrophenol is linked via a β-glycosidic bond to N-acetyl-β-D-glucosamine (GlcNAc). Its primary application is as a substrate for the enzyme N-acetyl-β-D-glucosaminidase (NAGase). When NAGase cleaves the glycosidic bond, it releases the yellow-colored 4-nitrophenolate ion, which can be quantified spectrophotometrically at around 405 nm. This reaction forms the basis for sensitive and convenient colorimetric assays. NAGase activity is a clinically important biomarker, particularly for monitoring renal tubular damage and certain lysosomal storage disorders. Due to its specific enzymatic reactivity, this compound is a key reagent in diagnostic kits and research tools for measuring NAGase activity in biological samples such as urine and serum. It is not typically used as a general synthetic building block but is specialized for enzymatic studies and diagnostic applications.

Physical Properties

Melting Point: 210-212 °C

Boiling Point: 694.7 °C at 760 mmHg

Flash Point: 374 °C

Density: 1.51 g/cm3

Solubility: H2O: 5 mg/mL, clear, colorless to very faintly yellow

Storage: −20°C