6-Bromopyridine-2-carbaldehyde, CAS No. 34160-40-2

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34160-40-2

Catalog No. EBD322611

CAS 34160-40-2

Name 6-Bromopyridine-2-carbaldehyde

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Basic Information

Synonyms: 6-bromo-pyridine-2-carboxaldehyde 6-Bromo-2-pyridinecarboxaldehyde 6-Bromopyridine-2-carboxaldehyde 6-Bromopyridine-2-carbaldehyde 2-Bromo-6-pyridinecarboxaldehyde

Molecular Formula: C6H4BrNO

Molecular Weight: 186.01

MDL Number: MFCD02683546

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

6-Bromopyridine-2-carbaldehyde is an important heterocyclic aromatic compound featuring both a bromine atom and an aldehyde group on a pyridine ring. This bifunctional structure makes it a versatile and valuable building block in organic synthesis, particularly for constructing more complex nitrogen-containing heterocycles. Its primary application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various bioactive molecules and drug candidates. For instance, it is used in the preparation of kinase inhibitors, such as certain c-Met inhibitors, and other therapeutic agents targeting neurological disorders and cancers. The reactive aldehyde group allows for condensation and cyclization reactions, while the bromine atom enables further functionalization via cross-coupling reactions (e.g., Suzuki, Stille). As a synthetic building block, it is commercially available and widely used in medicinal chemistry research for constructing pyridine-based scaffolds. Standard safety precautions for handling aldehydes and halogenated compounds should be observed.

Physical Properties

Melting Point: 81-85 °C(lit.)

Boiling Point: 248.2 °C at 760 mmHg

Flash Point: 103.9 °C

Density: 1.683 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: Light yellow flakes